Description
| 抗体名: | FUS Antibody (PACO09359) |
| 抗体コード: | PACO09359 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC, IF |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human FUS |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | fusion (involved in t(12;16) in malignant liposarcoma);FUS;CHOP;FUS-CHOP;FUS1;TLS;TLS/CHOP;hnRNP-P2 ; |
| UniProt Protein Function: | hnRNP P2: Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity. Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts through its C-terminus with SFRS13A. Interacts with OTUB1 and SARNP. Ubiquitous. Belongs to the RRM TET family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oncoprotein; RNA-binding; Nuclear receptor co-regulator; DNA-binding; RNA splicing Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:identical protein binding; protein binding; DNA binding; zinc ion binding; RNA binding; nucleotide binding Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression Disease: Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia; Tremor, Hereditary Essential, 4 |
| NCBI Summary: | This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009] |
| UniProt Code: | P35637 |
| NCBI GenInfo Identifier: | 544357 |
| NCBI Gene ID: | 2521 |
| NCBI Accession: | P35637.1 |
| UniProt Secondary Accession: | P35637,Q9H4A8, |
| UniProt Related Accession: | P35637 |
| Molecular Weight: | Calculated MW: 53kDaObserved MW: 70kDa |
| NCBI Full Name: | RNA-binding protein FUS |
| NCBI Synonym Full Names: | FUS RNA binding protein |
| NCBI Official Symbol: | FUS |
| NCBI Official Synonym Symbols: | TLS; ALS6; ETM4; FUS1; POMP75; HNRNPP2 |
| NCBI Protein Information: | RNA-binding protein FUS; oncogene FUS; oncogene TLS; fus-like protein; fused in sarcoma; 75 kDa DNA-pairing protein; fusion gene in myxoid liposarcoma; translocated in liposarcoma protein; heterogeneous nuclear ribonucleoprotein P2 |
| UniProt Protein Name: | RNA-binding protein FUS |
| UniProt Synonym Protein Names: | 75 kDa DNA-pairing protein; Oncogene FUS; Oncogene TLS; POMp75; Translocated in liposarcoma protein |
| Protein Family: | Fusion protein |
| UniProt Gene Name: | FUS |
| UniProt Entry Name: | FUS_HUMAN |
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