Description
| Product Name: | FSH Recombinant Protein |
| Product Code: | RPPB1307 |
| Size: | 500IU |
| Target: | FSH |
| Synonyms: | Follitropin subunit beta, Follicle-stimulating hormone beta subunit, FSH-beta, FSH-B, Follitropin beta chain, FSH. |
| Source: | Urine of post-menopausal women |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The FSH was lyophilized with no additives. |
| Solubility: | It is recommended to reconstitute the lyophilized Follicle Stimulating Hormone in sterile pyrogen free water at 2,000IU/1ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized FSH although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FSH-beta should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
Follicle stimulating hormone (FSH) is a hormone synthesised and secreted by gonadotropes in the anterior pituitary gland. FSH and LH act synergistically in reproductionIn women, in the ovary FSH stimulates the growth of immature Graafian follicles to maturation. As the follicle grows it releases inhibin, which shuts off the FSH production. In men, FSH enhances the production of androgen-binding proteinby the Sertoli cells of the testes and is critical for spermatogenesis. In both males and females, FSH stimulates the maturation of germ cells. In females, FSH initiates follicular growth, specifically affecting granulosa cells. With the concomitant rise in inhibin B FSH levels then decline in the late follicular phase. This seems to be critical in selecting only the most advanced follicle to proceed to ovulation. At the end of the luteal phase, there is a slight rise in FSH that seems to be of importance to start the next ovulatory cycle.Like its partner, LH, FSH release at the pituitary gland is controlled by pulses of gonadotropin-releasing hormone(GnRH). Those pulses, in turn, are subject to the estrogen feed-back from the gonads.
FSH Human is a glycoprotein produced from urine of post-menopausal women and having a total molecular mass of 30,000 Dalton.FSH is a heterodimeric hormone consisting of 92 amino acids a chain and 111 amino acids b chain.The FSH is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FSHB: Stimulates development of follicle and spermatogenesis in the reproductive organs. Defects in FSHB are a cause of isolated follicle- stimulating hormone deficiency (IFSHD). Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men. Belongs to the glycoprotein hormones subunit beta family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11p13 Cellular Component: cytoplasm; extracellular region Molecular Function:follicle-stimulating hormone activity; hormone activity; protein binding Biological Process: female gamete generation; female pregnancy; peptide hormone processing; progesterone biosynthetic process; signal transduction; transforming growth factor beta receptor signaling pathway Disease: Follicle-stimulating Hormone Deficiency, Isolated |
| NCBI Summary: | The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P01225 |
| NCBI GenInfo Identifier: | 120552 |
| NCBI Gene ID: | 2488 |
| NCBI Accession: | P01225.2 |
| UniProt Secondary Accession: | P01225,Q14D61, A2TF08, A5JVV3, |
| UniProt Related Accession: | P01225 |
| Molecular Weight: | 14,700 Da |
| NCBI Full Name: | Follitropin subunit beta |
| NCBI Synonym Full Names: | follicle stimulating hormone beta subunit |
| NCBI Official Symbol: | FSHB�� |
| NCBI Official Synonym Symbols: | HH24�� |
| NCBI Protein Information: | follitropin subunit beta |
| UniProt Protein Name: | Follitropin subunit beta |
| UniProt Synonym Protein Names: | Follicle-stimulating hormone beta subunit; FSH-B; FSH-beta; Follitropin beta chain |
| Protein Family: | Follitropin |
| UniProt Gene Name: | FSHB�� |
| UniProt Entry Name: | FSHB_HUMAN |
