Description
| 抗体名: | FOXD3 Antibody (PACO23291) |
| 抗体コード: | PACO23291 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
| 反応性: | Human, Mouse |
| 免疫原: | Synthesized peptide derived from internal of human FOXD3. |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HUVEC cells and 293 cells, using FOXD3 antibody. |
 | Immunohistochemistry analysis of paraffin-embedded human heart tissue using FOXD3 antibody. |
| バックグラウンド: | Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. |
| シノニム: | Forkhead box protein D3; HNF3/FH transcription factor genesis; FOXD3; |
| UniProt Protein Function: | FOXD3: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 1p31.3 Cellular Component: nucleoplasm; nuclear chromatin Molecular Function:protein binding; double-stranded DNA binding; transcription factor activity Biological Process: embryonic placenta development; transcription, DNA-dependent; somatic stem cell maintenance; in utero embryonic development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; trophectodermal cell differentiation Disease: Autoimmune Disease, Susceptibility To, 1 |
| NCBI Summary: | This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008] |
| UniProt Code: | Q9UJU5 |
| NCBI GenInfo Identifier: | 8134475 |
| NCBI Gene ID: | 27022 |
| NCBI Accession: | Q9UJU5.1 |
| UniProt Secondary Accession: | Q9UJU5,Q9BYM2, Q9UDD1, |
| UniProt Related Accession: | Q9UJU5 |
| Molecular Weight: | 478 |
| NCBI Full Name: | Forkhead box protein D3 |
| NCBI Synonym Full Names: | forkhead box D3 |
| NCBI Official Symbol: | FOXD3 |
| NCBI Official Synonym Symbols: | AIS1; HFH2; VAMAS2; Genesis |
| NCBI Protein Information: | forkhead box protein D3; HNF3/FH transcription factor genesis |
| UniProt Protein Name: | Forkhead box protein D3 |
| UniProt Synonym Protein Names: | HNF3/FH transcription factor genesis |
| Protein Family: | Forkhead box protein |
| UniProt Gene Name: | FOXD3 |
| UniProt Entry Name: | FOXD3_HUMAN |
| Antibodies | ELISA Kits |
| Anti-FOXD3 Antibody (CAB2926) | FOXD3 Transcription Factor Activity Assay |
| FOXD3 Antibody (PACO00818) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
