| UniProt Protein Function: | FMO5: In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme. Belongs to the FMO family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.14.13.8; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450 Chromosomal Location of Human Ortholog: 1q21.1 Cellular Component: endoplasmic reticulum membrane; integral to membrane Molecular Function:FAD binding; NADP binding; flavin-containing monooxygenase activity |
| NCBI Summary: | Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009] |
| UniProt Code: | P49326 |
| NCBI GenInfo Identifier: | 1346021 |
| NCBI Gene ID: | 2330 |
| NCBI Accession: | P49326.2 |
| UniProt Secondary Accession: | P49326,P97872, Q8K4C0, |
| UniProt Related Accession: | P49326 |
| Molecular Weight: | 533 |
| NCBI Full Name: | Dimethylaniline monooxygenase |
| NCBI Synonym Full Names: | flavin containing monooxygenase 5 |
| NCBI Official Symbol: | FMO5 |
| NCBI Protein Information: | dimethylaniline monooxygenase [N-oxide-forming] 5; dimethylaniline monooxygenase [N-oxide-forming] 5; FMO 5; dimethylaniline oxidase 5; hepatic flavin-containing monooxygenase 5 |
| UniProt Protein Name: | Dimethylaniline monooxygenase [N-oxide-forming] 5 |
| UniProt Synonym Protein Names: | Dimethylaniline oxidase 5; Hepatic flavin-containing monooxygenase 5; FMO 5 |
| Protein Family: | Dimethylaniline monooxygenase |
| UniProt Gene Name: | FMO5 |
| UniProt Entry Name: | FMO5_HUMAN |
