Description
Filamin A Rabbit Polyclonal Antibody (CAB16376)
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| Product Name: | Filamin A Rabbit Polyclonal Antibody |
| SKU: | CAB16376 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human,Mouse,Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2348-2647 of human Filamin A (NP_001104026.1). |
| Sequence: | NQPA SFAV SLNG AKGA IDAK VHSP SGAL EECY VTEI DQDK YAVR FIPR ENGV YLID VKFN GTHI PGSP FKIR VGEP GHGG DPGL VSAY GAGL EGGV TGNP AEFV VNTS NAGA GALS VTID GPSK VKMD CQEC PEGY RVTY TPMA PGSY LISI KYGG PYHI GGSP FKAK VTGP RLVS NHSL HETS SVFV DSLT KATC APQH GAPG PGPA DASK VVAK GLGL SKAY VGQK SSFT VDCS KAGN NMLL VGVH GPRT PCEE ILVK HVGS RLYS VSYL LKDK GEYT LVVK WGDE HIPG SPYR VVVP |
| Tested Applications: | WB IHC-P IF/ICC ELISA |
| Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
| Synonyms: | FLN; FMD; MNS; OPD; ABPX; CSBS; CVD1; FGS2; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280; Filamin A |
| Positive Sample: | Jurkat,HeLa,NIH/3T3,293T,U-251MG,Mouse lung |
| Conjugate: | Unconjugated |
| Cellular Localization: | Cytoplasm, cell cortex, cytoskeleton. |
| Calculated MW: | 281kDa |
| Observed MW: | 300kDa |
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
| Purification Method: | Affinity purification |
| Gene ID: | 2316 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
 | Western blot analysis of various lysates using Filamin A Rabbit pAb (CAB16376) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s. |
