Description
| 抗体名: | FDXR Antibody, HRP conjugated (PACO26722) |
| 抗体コード: | PACO26722 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human NADPH:adrenodoxin oxidoreductase, mitochondrial protein (33-451AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | HRP |
| バックグラウンド: | Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-β hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. |
| シノニム: | NADPH:adrenodoxin oxidoreductase, mitochondrial (AR) (Adrenodoxin reductase) (EC 1.18.1.6) (Ferredoxin--NADP(+) reductase) (Ferredoxin reductase), FDXR, ADXR |
| UniProt Protein Function: | FDXR: Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. Belongs to the ferredoxin--NADP reductase type 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Mitochondrial; EC 1.18.1.6 Chromosomal Location of Human Ortholog: 17q25.1 Cellular Component: mitochondrion; mitochondrial matrix Molecular Function:protein binding; ferredoxin-NADP+ reductase activity; NADPH-adrenodoxin reductase activity Biological Process: steroid metabolic process; cholesterol metabolic process; ubiquinone biosynthetic process; generation of precursor metabolites and energy; xenobiotic metabolic process; C21-steroid hormone biosynthetic process; steroid biosynthetic process; sterol metabolic process |
| NCBI Summary: | This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | P22570 |
| NCBI GenInfo Identifier: | 85681283 |
| NCBI Gene ID: | 2232 |
| NCBI Accession: | P22570.3 |
| UniProt Related Accession: | P22570 |
| Molecular Weight: | Observed Molecular Weight: (Observed)53kD.Predicted Molecular Weight: (Calculated)54kDa. |
| NCBI Full Name: | NADPH:adrenodoxin oxidoreductase, mitochondrial |
| NCBI Synonym Full Names: | ferredoxin reductase |
| NCBI Official Symbol: | FDXR |
| NCBI Official Synonym Symbols: | ADR; ADXR; ANOA |
| NCBI Protein Information: | NADPH:adrenodoxin oxidoreductase, mitochondrial |
| UniProt Protein Name: | NADPH:adrenodoxin oxidoreductase, mitochondrial |
| UniProt Synonym Protein Names: | Ferredoxin--NADP(+) reductase; Ferredoxin reductase |
| UniProt Gene Name: | FDXR |
| UniProt Entry Name: | ADRO_HUMAN |
