Description
| 抗体名: | FBXW5 Antibody, FITC conjugated (PACO46940) |
| 抗体コード: | PACO46940 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human F-box/WD repeat-containing protein 5 protein (265-494AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | FITC |
| バックグラウンド: | Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. |
| シノニム: | F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5), FBXW5, FBW5 |
| UniProt Protein Function: | FBXW5: Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Belongs to the FBXW5 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 9q34.3 Cellular Component: cytoplasm; SCF ubiquitin ligase complex Molecular Function:protein binding; protein kinase binding Biological Process: centrosome duplication; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| NCBI Summary: | This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q969U6 |
| NCBI GenInfo Identifier: | 44887886 |
| NCBI Gene ID: | 54461 |
| NCBI Accession: | Q969U6.1 |
| UniProt Secondary Accession: | Q969U6,Q59ET5, Q5SPZ8, Q5SPZ9, Q5SQ00, Q5SQ02, Q5SQ03 Q5SQ04, Q8WY79, Q96GJ6, Q9BSU8, B2RDZ6, |
| UniProt Related Accession: | Q969U6 |
| Molecular Weight: | 42,185 Da |
| NCBI Full Name: | F-box/WD repeat-containing protein 5 |
| NCBI Synonym Full Names: | F-box and WD repeat domain containing 5 |
| NCBI Official Symbol: | FBXW5 |
| NCBI Official Synonym Symbols: | Fbw5 |
| NCBI Protein Information: | F-box/WD repeat-containing protein 5 |
| UniProt Protein Name: | F-box/WD repeat-containing protein 5 |
| UniProt Synonym Protein Names: | F-box and WD-40 domain-containing protein 5 |
| Protein Family: | F-box/WD repeat-containing protein |
| UniProt Gene Name: | FBXW5 |
| UniProt Entry Name: | FBXW5_HUMAN |
