Description
| 抗体名: | FBXO7 Antibody (PACO44936) |
| 抗体コード: | PACO44936 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human F-box only protein 7 protein (353-522AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO44936 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human prostate cancer using PACO44936 at dilution of 1:100. |
| バックグラウンド: | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PARK2 to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. |
| シノニム: | F-box only protein 7, FBXO7, FBX7 |
| UniProt Protein Function: | FBXO7: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Defects in FBXO7 are the cause of Parkinson disease type 15 (PARK15); also known as parkinsonian-pyramidal syndrome. A neurodegenerative disorder characterized by parkinsonian and pyramidal signs. Clinical manifestations include tremor, bradykinesia, rigidity, postural instability, spasticity, mainly in the lower limbs, and hyperreflexia. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 22q12.3 Cellular Component: protein complex; mitochondrion; cytoplasm; nucleus; cytosol; ubiquitin ligase complex Molecular Function:protein binding; ubiquitin-protein ligase activity; protein kinase binding Biological Process: ubiquitin-dependent protein catabolic process; negative regulation of cyclin-dependent protein kinase activity; mitochondrion degradation; regulation of protein stability; protein ubiquitination; protein targeting to mitochondrion; negative regulation of lymphocyte differentiation Disease: Parkinson Disease 15, Autosomal Recessive Early-onset |
| NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y3I1 |
| NCBI GenInfo Identifier: | 13124249 |
| NCBI Gene ID: | 25793 |
| NCBI Accession: | Q9Y3I1.1 |
| UniProt Secondary Accession: | Q9Y3I1,Q5TGC4, Q5TI86, Q96HM6, Q9UF21, Q9UKT2, B4DNB3 B4DWX5, |
| UniProt Related Accession: | Q9Y3I1 |
| Molecular Weight: | 522 |
| NCBI Full Name: | F-box only protein 7 |
| NCBI Synonym Full Names: | F-box protein 7 |
| NCBI Official Symbol: | FBXO7 |
| NCBI Official Synonym Symbols: | FBX; FBX7; PKPS; FBX07; PARK15 |
| NCBI Protein Information: | F-box only protein 7 |
| UniProt Protein Name: | F-box only protein 7 |
| Protein Family: | F-box only protein |
| UniProt Gene Name: | FBXO7 |
| UniProt Entry Name: | FBX7_HUMAN |
