Description
| 抗体名: | FBXO22 Antibody (PACO45182) |
| 抗体コード: | PACO45182 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| 反応性: | Human, Mouse |
| 免疫原: | Recombinant Human F-box only protein 22 protein (104-403AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: FBXO22 antibody at 2.42 µg/ml. Lane 1: Mouse heart tissue. Lane 2: Mouse liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 45, 5, 31 kDa. Observed band size: 45 kDa.. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using PACO45182 at dilution of 1:100. |
| バックグラウンド: | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. |
| シノニム: | F-box only protein 22 (F-box protein FBX22p44), FBXO22, FBX22 |
| UniProt Protein Function: | FBXO22: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ligase Chromosomal Location of Human Ortholog: 15q24.2 Molecular Function:ubiquitin-protein ligase activity Biological Process: protein modification process; ubiquitin-dependent protein catabolic process |
| NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q8NEZ5 |
| NCBI GenInfo Identifier: | 30580428 |
| NCBI Gene ID: | 26263 |
| NCBI Accession: | Q8NEZ5.1 |
| UniProt Secondary Accession: | Q8NEZ5,Q0D2P8, Q6PIL5, Q8IXW3, Q9H824, Q9UKC0, |
| UniProt Related Accession: | Q8NEZ5 |
| Molecular Weight: | 30,589 Da |
| NCBI Full Name: | F-box only protein 22 |
| NCBI Synonym Full Names: | F-box protein 22 |
| NCBI Official Symbol: | FBXO22 |
| NCBI Official Synonym Symbols: | FBX22; FISTC1 |
| NCBI Protein Information: | F-box only protein 22 |
| UniProt Protein Name: | F-box only protein 22 |
| UniProt Synonym Protein Names: | F-box protein FBX22p44 |
| Protein Family: | F-box only protein |
| UniProt Gene Name: | FBXO22 |
| UniProt Entry Name: | FBX22_HUMAN |
