Description
| 抗体名: | FARP2 Antibody, FITC conjugated (PACO26687) |
| 抗体コード: | PACO26687 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human FERM, ARHGEF and pleckstrin domain-containing protein 2 protein (261-550AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | FITC |
| バックグラウンド: | Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). |
| シノニム: | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3), FARP2, KIAA0793 PLEKHC3 |
| UniProt Protein Function: | FARP2: Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: cytoplasm; cytoskeleton; cytosol Molecular Function:cytoskeletal protein binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity Biological Process: actin cytoskeleton reorganization; cell adhesion; hair cycle process; neuron remodeling; osteoclast differentiation; positive regulation of GTPase activity; Rac protein signal transduction; regulation of integrin activation; regulation of Rho protein signal transduction |
| UniProt Code: | O94887 |
| NCBI GenInfo Identifier: | 545478372 |
| NCBI Gene ID: | 9855 |
| NCBI Accession: | NP_001269912.1 |
| UniProt Secondary Accession: | O94887,Q53QM5, Q8WU27, Q9UFE7, B7Z6J8, F5GZ84, |
| UniProt Related Accession: | O94887 |
| Molecular Weight: | 119 kDa |
| NCBI Full Name: | FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform b |
| NCBI Synonym Full Names: | FERM, ARH/RhoGEF and pleckstrin domain protein 2 |
| NCBI Official Symbol: | FARP2 |
| NCBI Official Synonym Symbols: | FIR; FRG; PLEKHC3 |
| NCBI Protein Information: | FERM, ARHGEF and pleckstrin domain-containing protein 2; FERM, RhoGEF and pleckstrin domain-containing protein 2 |
| UniProt Protein Name: | FERM, ARHGEF and pleckstrin domain-containing protein 2 |
| UniProt Synonym Protein Names: | FERM domain-including RhoGEF; FIR; FERM, RhoGEF and pleckstrin domain-containing protein 2; Pleckstrin homology domain-containing family C member 3; PH domain-containing family C member 3 |
| UniProt Gene Name: | FARP2 |
