Description
| 抗体名: | EXOSC2 Antibody (PACO09169) |
| 抗体コード: | PACO09169 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC, IF |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human EXOSC2 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | exosome component 2;EXOSC2;RRP4;Rrp4p;hRrp4p;p7 ; |
| UniProt Protein Function: | RRP4: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7. |
| UniProt Protein Details: | Protein type:RNA processing; EC 3.1.13.-; Ribonuclease; Nucleolus Chromosomal Location of Human Ortholog: 9q34 Cellular Component: cytoplasm; nucleolus; exosome (RNase complex); cytosol; nucleus; nuclear exosome (RNase complex) Molecular Function:protein binding; 3'-5'-exoribonuclease activity; exoribonuclease activity; 7S RNA binding Biological Process: gene expression; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); positive regulation of cell growth; rRNA processing; mRNA catabolic process, deadenylation-dependent decay |
| UniProt Code: | Q13868 |
| NCBI GenInfo Identifier: | 13878748 |
| NCBI Gene ID: | 23404 |
| NCBI Accession: | Q13868.2 |
| UniProt Secondary Accession: | Q13868,Q9NUY4, A3KFL3, B4DKK6, |
| UniProt Related Accession: | Q13868 |
| Molecular Weight: | 293 |
| NCBI Full Name: | Exosome complex component RRP4 |
| NCBI Synonym Full Names: | exosome component 2 |
| NCBI Official Symbol: | EXOSC2 |
| NCBI Official Synonym Symbols: | p7; RRP4; Rrp4p; hRrp4p |
| NCBI Protein Information: | exosome complex component RRP4; exosome complex exonuclease RRP4; ribosomal RNA-processing protein 4; homolog of yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease; homolog of yeast RRP4 (ribosomal RNA processing 4), 3' 5' exoribonuclease (RRP4) |
| UniProt Protein Name: | Exosome complex component RRP4 |
| UniProt Synonym Protein Names: | Exosome component 2; Ribosomal RNA-processing protein 4 |
| UniProt Gene Name: | EXOSC2 |
| UniProt Entry Name: | EXOS2_HUMAN |
