Description
| 抗体名: | EIF2B2 Antibody (PACO44495) |
| 抗体コード: | PACO44495 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Translation initiation factor eIF-2B subunit β protein (1-351AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO44495 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO44495 at dilution of 1:100. |
| バックグラウンド: | Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. |
| シノニム: | Translation initiation factor eIF-2B subunit β (S20I15) (S20III15) (eIF-2B GDP-GTP exchange factor subunit beta), EIF2B2, EIF2BB |
| UniProt Protein Function: | eIF2B-beta: eukaryotic translation initiation factor 2B, subunit 5. A translational regulatory protein that functions in the early steps of protein synthesis by catalyzing the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutation in EIF2B5 causes childhood ataxia with central nervous system hypomyelination/ vanishing white matter leukodystrophy. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; RNA-binding; Translation; GEFs; GEFs, misc. Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: eukaryotic translation initiation factor 2B complex; cytoplasm; cytosol Molecular Function:protein binding; GTP binding; guanyl-nucleotide exchange factor activity; translation initiation factor activity; S-methyl-5-thioribose-1-phosphate isomerase activity; ATP binding Biological Process: myelination; response to peptide hormone stimulus; central nervous system development; translation; cellular response to stimulus; cellular protein metabolic process; ovarian follicle development; methionine salvage; response to heat; translational initiation; response to glucose stimulus; gene expression; oligodendrocyte development; regulation of translational initiation; positive regulation of GTPase activity Disease: Leukoencephalopathy With Vanishing White Matter |
| NCBI Summary: | This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P49770 |
| NCBI GenInfo Identifier: | 6226858 |
| NCBI Gene ID: | 8892 |
| NCBI Accession: | P49770.3 |
| UniProt Secondary Accession: | P49770,Q99LD9, Q62818, |
| UniProt Related Accession: | P49770 |
| Molecular Weight: | 351 |
| NCBI Full Name: | Translation initiation factor eIF-2B subunit beta |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa |
| NCBI Official Symbol: | EIF2B2 |
| NCBI Official Synonym Symbols: | EIF2B; EIF-2Bbeta |
| NCBI Protein Information: | translation initiation factor eIF-2B subunit beta; S20I15; S20III15; eIF-2B GDP-GTP exchange factor subunit beta |
| UniProt Protein Name: | Translation initiation factor eIF-2B subunit beta |
| UniProt Synonym Protein Names: | S20I15; S20III15; eIF-2B GDP-GTP exchange factor subunit beta |
| Protein Family: | Translation initiation factor |
| UniProt Gene Name: | EIF2B2 |
| UniProt Entry Name: | EI2BB_HUMAN |
