| NCBI Summary: | The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q9NZJ5 |
| NCBI GenInfo Identifier: | 296439367 |
| NCBI Gene ID: | 9451 |
| NCBI Accession: | |
| UniProt Related Accession: | Q9NZJ5 |
| Molecular Weight: | 170 |
| NCBI Full Name: | Eukaryotic translation initiation factor 2-alpha kinase 3 |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 2 alpha kinase 3 |
| NCBI Official Symbol: | EIF2AK3 |
| NCBI Official Synonym Symbols: | PEK; WRS; PERK |
| NCBI Protein Information: | eukaryotic translation initiation factor 2-alpha kinase 3 |
| UniProt Protein Name: | |
| UniProt Gene Name: | |
