Description
| 抗体名: | EHF Antibody (PACO44627) |
| 抗体コード: | PACO44627 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| 反応性: | Human, Mouse |
| 免疫原: | Recombinant Human ETS homologous factor protein (1-210AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: EHF antibody at 4.95µg/ml. Lane 1: Mouse brain tissue. Lane 2: Mouse lung tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 35, 33, 38 kDa. Observed band size: 35, 45, 63 kDa.. |
 | Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO44627 at dilution of 1:100. |
| バックグラウンド: | Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene. |
| シノニム: | ETS homologous factor (hEHF) (ETS domain-containing transcription factor) (Epithelium-specific Ets transcription factor 3) (ESE-3), EHF, ESE3 ESE3B ESEJ |
| UniProt Protein Function: | EHF: Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen- activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets- binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene. Belongs to the ETS family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 11p12 Cellular Component: nucleoplasm; Golgi apparatus; nucleus Molecular Function:DNA binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; cell proliferation; epithelial cell differentiation; multicellular organismal development; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] |
| UniProt Code: | Q9NZC4 |
| NCBI GenInfo Identifier: | 74762761 |
| NCBI Gene ID: | 26298 |
| NCBI Accession: | Q9NZC4.1 |
| UniProt Secondary Accession: | Q9NZC4,Q9H509, Q9UKF9, Q9Y5V4, Q9Y5V5, D3DR08, D3DR10 E9PSB2, |
| UniProt Related Accession: | Q9NZC4 |
| Molecular Weight: | 37,356 Da |
| NCBI Full Name: | ETS homologous factor |
| NCBI Synonym Full Names: | ets homologous factor |
| NCBI Official Symbol: | EHF |
| NCBI Official Synonym Symbols: | ESE3; ESEJ; ESE3B |
| NCBI Protein Information: | ETS homologous factor; EHF; hEHF; ESE3 transcription factor; ETS domain-containing transcription factor; epithelium-specific Ets transcription factor 3 |
| UniProt Protein Name: | ETS homologous factor |
| UniProt Synonym Protein Names: | ETS domain-containing transcription factor; Epithelium-specific Ets transcription factor 3; ESE-3 |
| Protein Family: | ETS homologous factor |
| UniProt Gene Name: | EHF |
| UniProt Entry Name: | EHF_HUMAN |
