The EDAR Polyclonal Antibody (CAB4461) is specifically designed for researchers studying EDAR, a cell surface receptor involved in hair, skin, and sweat gland development. This antibody, produced in rabbits, is highly sensitive and reacts specifically with human samples, making it a reliable tool for Western blot applications. By binding to the EDAR protein, this antibody enables the detection and analysis of EDAR in various cell types, making it ideal for studies in developmental biology and dermatology.EDAR, or Ectodysplasin A receptor, is known for its role in the development of ectodermal tissues, including hair, teeth, and sweat glands. Understanding the function of EDAR is essential for unraveling the mechanisms underlying ectodermal development and related disorders.
Research on EDAR can provide insights into conditions such as hypohidrotic ectodermal dysplasia, a genetic disorder affecting the development of hair, teeth, and sweat glands.By utilizing the EDAR Polyclonal Antibody, researchers can delve deeper into the molecular mechanisms regulated by EDAR and its implications in developmental biology and dermatological research. This antibody is a valuable tool for investigating the role of EDAR in ectodermal tissue development and potentially advancing our understanding and treatment of related disorders.
Product Name:
EDAR Rabbit Polyclonal Antibody
SKU:
CAB4461
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 27-187 of human EDAR (NP_071731.1).
This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.
Purification Method:
Affinity purification
Gene ID:
10913
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using EDAR antibody (CAB4461) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
