Description
| 抗体名: | DYNC1I1 Antibody (PACO45076) |
| 抗体コード: | PACO45076 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| 反応性: | Human, Mouse |
| 免疫原: | Recombinant Human Cytoplasmic dynein 1 intermediate chain 1 protein (1-220AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: DYNC1I1 antibody at 2.52µg/ml. Lane 1: Mouse brain tissue. Lane 2: Mouse gonadal tissue. Lane 3: K562 whole cell lysate. Lane 4: HL60 whole cell lysate. Lane 5: Mouse lung tissue. Lane 6: Mouse skeletal muscle tissue. Lane 7: Mouse stomach tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 73, 71, 69, 68 kDa. Observed band size: 73 kDa.. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO45076 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO45076 at dilution of 1:100. |
| バックグラウンド: | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores. |
| シノニム: | Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1), DYNC1I1, DNCI1 DNCIC1 |
| UniProt Protein Function: | DYNC1I1: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores. Belongs to the dynein intermediate chain family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Microtubule-binding; Motor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 7q21.3 Cellular Component: kinetochore; spindle pole; microtubule; recycling endosome; cytoplasmic dynein complex; perinuclear region of cytoplasm; cytosol; vesicle Molecular Function:protein binding; spectrin binding; microtubule binding; motor activity; microtubule motor activity Biological Process: metabolic process; vesicle transport along microtubule; antigen processing and presentation of exogenous peptide antigen via MHC class II |
| UniProt Code: | O14576 |
| NCBI GenInfo Identifier: | 6647481 |
| NCBI Gene ID: | 1780 |
| NCBI Accession: | O14576.2 |
| UniProt Related Accession: | O14576 |
| Molecular Weight: | Observed Molecular Weight: (Observed)72kD.Predicted Molecular Weight: (Calculated)73kDa. |
| NCBI Full Name: | Cytoplasmic dynein 1 intermediate chain 1 |
| NCBI Synonym Full Names: | dynein cytoplasmic 1 intermediate chain 1 |
| NCBI Official Symbol: | DYNC1I1 |
| NCBI Official Synonym Symbols: | DNCI1; DNCIC1 |
| NCBI Protein Information: | cytoplasmic dynein 1 intermediate chain 1 |
| UniProt Protein Name: | Cytoplasmic dynein 1 intermediate chain 1 |
| UniProt Synonym Protein Names: | Cytoplasmic dynein intermediate chain 1; Dynein intermediate chain 1, cytosolic; DH IC-1 |
| Protein Family: | Cytoplasmic dynein |
| UniProt Gene Name: | DYNC1I1 |
| UniProt Entry Name: | DC1I1_HUMAN |
