Description
| 抗体名: | DUSP16 Antibody (PACO45288) |
| 抗体コード: | PACO45288 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Dual specificity protein phosphatase 16 protein (416-665AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human lung tissue using PACO45288 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO45288 at dilution of 1:100. |
| バックグラウンド: | Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. |
| シノニム: | Dual specificity protein phosphatase 16 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7), DUSP16, KIAA1700 MKP7 |
| UniProt Protein Function: | MKP-7: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP16 suppresses MAPK activation in the order of selectivity, JNK >> p38 > ERK, but interacts with ERK as well as JNK and p38. Overexpression of DUSP16 in BCR-ABL-transformed fibroblasts reduces their transforming capacity in vitro and in vivo via down regulation of BCR-ABL-induced JNK activation. DUSP16 might be haploinsufficient for tumor suppression. Contains 1 rhodanese domain. |
| UniProt Protein Details: | Protein type:EC 3.1.3.48; Protein phosphatase, dual-specificity; EC 3.1.3.16 Chromosomal Location of Human Ortholog: 12p13 Cellular Component: nucleoplasm; cytoplasm; cytoplasmic membrane-bound vesicle; nucleus; cytosol Molecular Function:protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity Biological Process: MAPK export from nucleus; dephosphorylation; MAPK phosphatase export from nucleus, leptomycin B sensitive; protein amino acid dephosphorylation; inactivation of MAPK activity |
| NCBI Summary: | This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010] |
| UniProt Code: | Q9BY84 |
| NCBI GenInfo Identifier: | 38372911 |
| NCBI Gene ID: | 80824 |
| NCBI Accession: | NP_085143.1 |
| UniProt Secondary Accession: | Q9BY84,Q547C7, Q9C0G3, |
| UniProt Related Accession: | Q9BY84 |
| Molecular Weight: | 73,102 Da |
| NCBI Full Name: | dual specificity protein phosphatase 16 |
| NCBI Synonym Full Names: | dual specificity phosphatase 16 |
| NCBI Official Symbol: | DUSP16 |
| NCBI Official Synonym Symbols: | MKP7; MKP-7 |
| NCBI Protein Information: | dual specificity protein phosphatase 16; MAPK phosphatase-7; MAP kinase phosphatase 7; mitogen-activated protein kinase phosphatase 7 |
| UniProt Protein Name: | Dual specificity protein phosphatase 16 |
| UniProt Synonym Protein Names: | Mitogen-activated protein kinase phosphatase 7 |
| UniProt Gene Name: | DUSP16 |
| UniProt Entry Name: | DUS16_HUMAN |
