Description
| 抗体名: | DPYSL2 Antibody |
| 抗体コード: | PACO02598 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | synthesized peptide derived from human CRMP-2 around the non-phosphorylation site of T509. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | DPYSL2; CRMP2; ULIP2; Dihydropyrimidinase-related protein 2; DRP-2; Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2 |
| UniProt Protein Function: | CRMP-2: a microtubule-binding protein necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Homotetramer, and heterotetramer with CRMP1, CRMP-3, CRMP-4, or CRMP-5. Interacts through its C-terminus with the C-terminus of CYFIP1. Interacts with 5-hydroxytryptamine receptor 4 (5-HT(4)). |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Microtubule-binding Chromosomal Location of Human Ortholog: 8p22-p21 Cellular Component: microtubule; growth cone; mitochondrion; membrane; cell soma; dendrite; terminal button; cytosol Molecular Function:protein binding; dihydropyrimidinase activity; protein kinase binding Biological Process: response to drug; axon guidance; nervous system development; olfactory bulb development; response to amphetamine; synaptic vesicle transport; positive regulation of glutamate secretion; cytoskeleton organization and biogenesis; endocytosis; signal transduction; response to cocaine; pyrimidine base catabolic process; spinal cord development; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| NCBI Summary: | This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q16555 |
| NCBI GenInfo Identifier: | 3122051 |
| NCBI Gene ID: | 1808 |
| NCBI Accession: | Q16555.1 |
| UniProt Secondary Accession: | Q16555,O00424, A8K5H2, B4DR31, D3DSS7, |
| UniProt Related Accession: | Q16555 |
| Molecular Weight: | |
| NCBI Full Name: | Dihydropyrimidinase-related protein 2 |
| NCBI Synonym Full Names: | dihydropyrimidinase-like 2 |
| NCBI Official Symbol: | DPYSL2 |
| NCBI Official Synonym Symbols: | DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2 |
| NCBI Protein Information: | dihydropyrimidinase-related protein 2; collapsin response mediator protein hCRMP-2; unc-33-like phosphoprotein 2 |
| UniProt Protein Name: | Dihydropyrimidinase-related protein 2 |
| UniProt Synonym Protein Names: | Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2 |
| Protein Family: | Dihydropyrimidinase-related protein |
| UniProt Gene Name: | DPYSL2 |
| UniProt Entry Name: | DPYL2_HUMAN |
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