| UniProt Protein Function: | Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). |
| NCBI Summary: | This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q9BQC3 |
| NCBI GenInfo Identifier: | 74761201 |
| NCBI Gene ID: | 1802 |
| NCBI Accession: | Q9BQC3.1 |
| UniProt Secondary Accession: | Q9BQC3,O60623, A8MVC9, B2RDE3, B4DNI8, |
| UniProt Related Accession: | Q9BQC3 |
| Molecular Weight: | 38,510 Da |
| NCBI Full Name: | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 |
| NCBI Synonym Full Names: | DPH2 homolog |
| NCBI Official Symbol: | DPH2 |
| NCBI Official Synonym Symbols: | DPH2L2 |
| NCBI Protein Information: | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; diphthamide biosynthesis protein 2 |
| UniProt Protein Name: | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 |
| UniProt Synonym Protein Names: | Diphthamide biosynthesis protein 2; Diphtheria toxin resistance protein 2Curated; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2Curated |
| Protein Family: | 2-(3-amino-3-carboxypropyl)histidine synthase |
| UniProt Gene Name: | DPH2 |
