Description
| 抗体名: | DOK2 Antibody, FITC conjugated (PACO45780) |
| 抗体コード: | PACO45780 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Docking protein 2 protein (123-412AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | FITC |
| バックグラウンド: | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). |
| シノニム: | Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)), DOK2 |
| UniProt Protein Function: | DOK2: a member of the p62dok family of proteins that interact with receptor tyrosine kinases and mediate particular biological responses. Constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/Abl), a chimeric protein whose presence is associated with CML. Contains a pleckstrin homology domain at the amino terminus, 13 potential tyrosine phosphorylation sites, and six PXXP SH3 recognition motifs. Binds p120 (RasGAP) from CML cells. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 8p21.3 Cellular Component: cytosol Molecular Function:insulin receptor binding; protein binding; receptor signaling protein activity; transmembrane receptor protein tyrosine kinase adaptor protein activity Biological Process: blood coagulation; cell surface receptor linked signal transduction; leukocyte migration; Ras protein signal transduction; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway |
| NCBI Summary: | The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60496 |
| NCBI GenInfo Identifier: | 143220234 |
| NCBI Gene ID: | 9046 |
| NCBI Accession: | O60496.2 |
| UniProt Secondary Accession: | O60496,Q8N5A4, |
| UniProt Related Accession: | O60496 |
| Molecular Weight: | 45,379 Da |
| NCBI Full Name: | Docking protein 2 |
| NCBI Synonym Full Names: | docking protein 2 |
| NCBI Official Symbol: | DOK2 |
| NCBI Official Synonym Symbols: | p56DOK; p56dok-2 |
| NCBI Protein Information: | docking protein 2 |
| UniProt Protein Name: | Docking protein 2 |
| UniProt Synonym Protein Names: | Downstream of tyrosine kinase 2; p56(dok-2) |
| Protein Family: | Docking protein |
| UniProt Gene Name: | DOK2 |
| UniProt Entry Name: | DOK2_HUMAN |
