Description
| 抗体名: | DOK1 Antibody |
| 抗体コード: | PACO02594 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC, IF |
| 推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | synthesized peptide derived from human Dok-1 around the non-phosphorylation site of Y362. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | DOK1; Docking protein 1; Downstream of tyrosine kinase 1; p62(dok); pp62 |
| UniProt Protein Function: | DOK1: a docking protein that interacts with receptor tyrosine kinases. It is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 2p13 Cellular Component: perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus Molecular Function:protein binding; receptor signaling protein activity; insulin receptor binding Biological Process: cell surface receptor linked signal transduction; Ras protein signal transduction; insulin receptor signaling pathway; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway |
| NCBI Summary: | The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] |
| UniProt Code: | Q99704 |
| NCBI GenInfo Identifier: | 17366642 |
| NCBI Gene ID: | 1796 |
| NCBI Accession: | Q99704.1 |
| UniProt Secondary Accession: | Q99704,O43204, Q53TY2, Q9UHG6, |
| UniProt Related Accession: | Q99704 |
| Molecular Weight: | 481 |
| NCBI Full Name: | Docking protein 1 |
| NCBI Synonym Full Names: | docking protein 1, 62kDa (downstream of tyrosine kinase 1) |
| NCBI Official Symbol: | DOK1 |
| NCBI Official Synonym Symbols: | P62DOK |
| NCBI Protein Information: | docking protein 1; pp62; p62(dok); Downstream of tyrosine kinase 1; docking protein 1 (downstream of tyrosine kinase 1) |
| UniProt Protein Name: | Docking protein 1 |
| UniProt Synonym Protein Names: | Downstream of tyrosine kinase 1; p62(dok); pp62 |
| Protein Family: | Docking protein |
| UniProt Gene Name: | DOK1 |
| UniProt Entry Name: | DOK1_HUMAN |
