The DMC1 Polyclonal Antibody (CAB4491) is a valuable tool for researchers studying the DNA meiotic recombinase DMC1. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in various applications including Western blotting. By binding specifically to the DMC1 protein, this antibody enables precise detection and analysis in different cell types, making it ideal for studies in genetics, meiosis, and DNA repair mechanisms.
DMC1 is an essential protein involved in homologous recombination during meiosis, playing a crucial role in the repair of DNA double-strand breaks. Understanding the function and regulation of DMC1 is key to unraveling the mechanisms underlying genetic diversity and genome stability. Research focused on DMC1 may provide insights into the molecular basis of genetic disorders and cancer, as well as potential therapeutic strategies targeting DNA repair pathways.
Product Name:
DMC1 Rabbit Polyclonal Antibody
SKU:
CAB4491
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DMC1 (NP_008999.2).
This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
11144
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DMC1 antibody (CAB4491) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
