Description
| 抗体名: | DLX3 Antibody |
| 抗体コード: | PACO00709 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
| 反応性: | Human, Mouse |
| 免疫原: | synthesized peptide derived from the Internal region of human Dlx-3. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | DLX3; Homeobox protein DLX-3 |
| UniProt Protein Function: | DLX3: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis. Defects in DLX3 are a cause of trichodentoosseous syndrome (TDO). TDO is an autosomal dominant syndrome characterized by enamel hypoplasia and hypocalcification with associated strikingly curly hair. Defects in DLX3 are the cause of amelogenesis imperfecta type 4 (AI4); also known as amelogenesis imperfecta hypomaturation-hypoplastic type with taurodontism. AI4 is an autosomal dominant defect of enamel formation associated with enlarged pulp chambers. Belongs to the distal-less homeobox family. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 17q21.33 Molecular Function:transcription factor activity Disease: Amelogenesis Imperfecta, Type Iv; Trichodentoosseous Syndrome |
| NCBI Summary: | Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60479 |
| NCBI GenInfo Identifier: | 3913487 |
| NCBI Gene ID: | 1747 |
| NCBI Accession: | O60479.1 |
| UniProt Secondary Accession: | O60479,B3KQL6, |
| UniProt Related Accession: | O60479 |
| Molecular Weight: | 31,738 Da |
| NCBI Full Name: | Homeobox protein DLX-3 |
| NCBI Synonym Full Names: | distal-less homeobox 3 |
| NCBI Official Symbol: | DLX3 |
| NCBI Official Synonym Symbols: | AI4; TDO |
| NCBI Protein Information: | homeobox protein DLX-3 |
| UniProt Protein Name: | Homeobox protein DLX-3 |
| Protein Family: | Distal-less-like protein |
| UniProt Gene Name: | DLX3 |
