Description
| 抗体名: | DLC1 Antibody (PACO23278) |
| 抗体コード: | PACO23278 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC, IF |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:50-1:100, IF:1:100-1:500 |
| 反応性: | Human, Mouse |
| 免疫原: | Synthesized peptide derived from internal of human RHG07. |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue, using RHG07 antibody. |
 | Immunofluorescence analysis of A549 cells, using RHG07 antibody. |
| バックグラウンド: | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. |
| シノニム: | Rho-type GTPase-activating protein 7; Deleted in liver cancer 1 protein; Dlc-1; HP protein; StAR-related lipid transfer protein 12 |
| UniProt Protein Function: | DLC1: Functions as a GTPase-activating protein specific for Rho and an activator of PLCD1 in vivo and induces morphological changes and detachment through cytoskeletal reorganization. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Rac/Rho; Tumor suppressor Chromosomal Location of Human Ortholog: 8p22 Cellular Component: cortical actin cytoskeleton; focal adhesion; cytoplasm; caveola; cytosol; nucleus Molecular Function:protein binding; SH2 domain binding; lipid binding Biological Process: caspase activation; focal adhesion formation; heart morphogenesis; hindbrain morphogenesis; negative regulation of stress fiber formation; apoptosis; negative regulation of focal adhesion formation; positive regulation of protein amino acid dephosphorylation; regulation of cell shape; negative regulation of cell proliferation; regulation of small GTPase mediated signal transduction; negative regulation of Rho protein signal transduction; small GTPase mediated signal transduction; regulation of actin cytoskeleton organization and biogenesis; neural tube closure; forebrain development; actin cytoskeleton organization and biogenesis; negative regulation of cell migration Disease: Colorectal Cancer |
| NCBI Summary: | This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010] |
| UniProt Code: | Q96QB1 |
| NCBI GenInfo Identifier: | 313104315 |
| NCBI Gene ID: | 10395 |
| NCBI Accession: | Q96QB1.4 |
| UniProt Secondary Accession: | Q96QB1,O14868, O43199, Q7Z5R8, Q86UC6, Q9C0E0, Q9H7A2 B4DR10, B8PTI0, E9PDZ8, E9PF76, E9PGY9, |
| UniProt Related Accession: | Q96QB1 |
| Molecular Weight: | 1528 |
| NCBI Full Name: | Rho GTPase-activating protein 7 |
| NCBI Synonym Full Names: | DLC1 Rho GTPase activating protein |
| NCBI Official Symbol: | DLC1 |
| NCBI Official Synonym Symbols: | HP; ARHGAP7; STARD12; p122-RhoGAP |
| NCBI Protein Information: | rho GTPase-activating protein 7; Rho-GTPase-activating protein 7; deleted in liver cancer 1 protein; START domain-containing protein 12; deleted in liver cancer 1 variant 2; rho-type GTPase-activating protein 7; StAR-related lipid transfer (START) domain containing 12 |
| UniProt Protein Name: | Rho GTPase-activating protein 7 |
| UniProt Synonym Protein Names: | Deleted in liver cancer 1 protein; DLC-1; HP protein; Rho-type GTPase-activating protein 7; START domain-containing protein 12; StARD12; StAR-related lipid transfer protein 12 |
| Protein Family: | Dynein |
| UniProt Gene Name: | DLC1 |
| UniProt Entry Name: | RHG07_HUMAN |
