Description
| 抗体名: | DHODH Antibody |
| 抗体コード: | PACO02586 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
| 反応性: | Human |
| 免疫原: | synthesized peptide derived from the Internal region of human DHODH. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | DHODH; Dihydroorotate dehydrogenase; quinone); mitochondrial; DHOdehase; Dihydroorotate oxidase |
| UniProt Protein Function: | DHODH: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS); also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases. Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. |
| UniProt Protein Details: | Protein type:Mitochondrial; EC 1.3.5.2; Nucleotide Metabolism - pyrimidine; Membrane protein, integral; Oxidoreductase Chromosomal Location of Human Ortholog: 16q22 Cellular Component: cytoplasm; mitochondrial inner membrane; mitochondrion; nucleoplasm Molecular Function:dihydroorotate dehydrogenase activity Biological Process: 'de novo' pyrimidine base biosynthetic process; pyrimidine nucleoside biosynthetic process Disease: Postaxial Acrofacial Dysostosis |
| NCBI Summary: | The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q02127 |
| NCBI GenInfo Identifier: | 56405372 |
| NCBI Gene ID: | 1723 |
| NCBI Accession: | Q02127.3 |
| UniProt Secondary Accession: | Q02127,Q6P176, A8K8C8, |
| UniProt Related Accession: | Q02127 |
| Molecular Weight: | 42,867 Da |
| NCBI Full Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
| NCBI Synonym Full Names: | dihydroorotate dehydrogenase (quinone) |
| NCBI Official Symbol: | DHODH |
| NCBI Official Synonym Symbols: | URA1; POADS; DHOdehase |
| NCBI Protein Information: | dihydroorotate dehydrogenase (quinone), mitochondrial |
| UniProt Protein Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
| UniProt Synonym Protein Names: | Dihydroorotate oxidase |
| UniProt Gene Name: | DHODH |
| UniProt Entry Name: | PYRD_HUMAN |
