Description
| 抗体名: | DGKZ Antibody (PACO50538) |
| 抗体コード: | PACO50538 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IF |
| 推奨される希釈: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Diacylglycerol kinase zeta protein (11-152AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of Hela cells using PACO50538 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| バックグラウンド: | Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity. |
| シノニム: | Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta), DGKZ, DAGK6 |
| UniProt Protein Function: | DGKZ: Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity. Belongs to the eukaryotic diacylglycerol kinase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Kinase, lipid; EC 2.7.1.107; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: lamellipodium; nucleoplasm; nucleus; plasma membrane Molecular Function:diacylglycerol kinase activity; protein binding Biological Process: platelet activation |
| NCBI Summary: | The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010] |
| UniProt Code: | Q13574 |
| NCBI GenInfo Identifier: | 215274170 |
| NCBI Gene ID: | 8525 |
| NCBI Accession: | Q13574.3 |
| UniProt Secondary Accession: | Q13574,O00542, Q6ZVG7, Q8IVW9, B7Z2M9, B7Z6M3, E9PPW4 F6UCU9, G3V0F6, J3KNJ6, |
| UniProt Related Accession: | Q13574 |
| Molecular Weight: | 104,296 Da |
| NCBI Full Name: | Diacylglycerol kinase zeta |
| NCBI Synonym Full Names: | diacylglycerol kinase zeta |
| NCBI Official Symbol: | DGKZ |
| NCBI Official Synonym Symbols: | DAGK5; DAGK6; DGK-ZETA; hDGKzeta |
| NCBI Protein Information: | diacylglycerol kinase zeta |
| UniProt Protein Name: | Diacylglycerol kinase zeta |
| UniProt Synonym Protein Names: | Diglyceride kinase zeta; DGK-zeta |
| Protein Family: | Diacylglycerol kinase |
| UniProt Gene Name: | DGKZ |
| UniProt Entry Name: | DGKZ_HUMAN |
