Description
| 抗体名: | DES Antibody |
| 抗体コード: | PACO00699 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | synthesized peptide derived from human Desmin around the non-phosphorylation site of S60. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | DES; Desmin |
| UniProt Protein Function: | desmin: a class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 2q35 Cellular Component: intermediate filament; fascia adherens; cytosol; neuromuscular junction; Z disc; sarcolemma Molecular Function:identical protein binding; protein binding; structural constituent of cytoskeleton; cytoskeletal protein binding Biological Process: muscle contraction; cytoskeleton organization and biogenesis; regulation of heart contraction; muscle filament sliding Disease: Cardiomyopathy, Dilated, 1i; Scapuloperoneal Syndrome, Neurogenic, Kaeser Type; Myopathy, Myofibrillar, 1; Muscular Dystrophy, Limb-girdle, Type 2r |
| NCBI Summary: | This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P17661 |
| NCBI GenInfo Identifier: | 6686280 |
| NCBI Gene ID: | 1674 |
| NCBI Accession: | P17661.3 |
| UniProt Secondary Accession: | P17661,Q15787, Q549R7, Q549R8, Q549R9, Q8IZR1, Q8IZR6 Q8NES2, Q8NEU6, Q8TAC4, Q8TCX2, Q8TD99, |
| UniProt Related Accession: | P17661 |
| Molecular Weight: | |
| NCBI Full Name: | Desmin |
| NCBI Synonym Full Names: | desmin |
| NCBI Official Symbol: | DES |
| NCBI Official Synonym Symbols: | CSM1; CSM2; LGMD2R |
| NCBI Protein Information: | desmin; mutant desmin p.K241E; intermediate filament protein |
| UniProt Protein Name: | Desmin |
| Protein Family: | Desmin |
| UniProt Gene Name: | DES |
| UniProt Entry Name: | DESM_HUMAN |
