Description
| 抗体名: | DAB2 Antibody (PACO08733) |
| 抗体コード: | PACO08733 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human DAB2 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila);DAB2;DOC-2;DOC2;FLJ26626 ; |
| UniProt Protein Function: | DAB2: an adaptor protein that interacts with Grb2, myosin VI, SMAD2/3, DIP1/2, Dvl-3, the integrin betasubunit, and c-Src. Negatively regulates canonical Wnt signaling by stabilizing the beta-catenin degradation complex. A component of the CSF-1 signal transduction pathway. Phosphorylated DAB2 inhibits adhesion and integrin signaling. Two alternatively spliced isoforms are described. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Tumor suppressor Chromosomal Location of Human Ortholog: 5p13.1 Cellular Component: focal adhesion; clathrin-coated vesicle; intracellular membrane-bound organelle; lysosomal membrane; apical plasma membrane; nucleolus; plasma membrane; clathrin coated vesicle membrane; coated pit; clathrin coat of coated pit Molecular Function:protein C-terminus binding; integrin binding; protein binding; phosphatidylinositol-4,5-bisphosphate binding; SMAD binding Biological Process: cellular morphogenesis during differentiation; pinocytosis; apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of endocytosis; excretion; activation of JNK activity; clathrin cage assembly; protein transport; positive regulation of RNA elongation from RNA polymerase II promoter; negative regulation of protein binding; positive regulation of receptor recycling; integrin-mediated signaling pathway; receptor-mediated endocytosis; Wnt receptor signaling pathway; in utero embryonic development; leading edge cell differentiation; positive regulation of transforming growth factor beta receptor signaling pathway; cell proliferation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; myeloid cell differentiation; positive regulation of protein amino acid phosphorylation; negative regulation of transcription, DNA-dependent; positive regulation of cell migration; endoderm development; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | P98082 |
| NCBI GenInfo Identifier: | 145559465 |
| NCBI Gene ID: | 1601 |
| NCBI Accession: | P98082.3 |
| UniProt Related Accession: | P98082 |
| Molecular Weight: | 60kDa |
| NCBI Full Name: | Disabled homolog 2 |
| NCBI Synonym Full Names: | DAB adaptor protein 2 |
| NCBI Official Symbol: | DAB2 |
| NCBI Official Synonym Symbols: | DOC2; DOC-2 |
| NCBI Protein Information: | disabled homolog 2 |
| UniProt Protein Name: | Disabled homolog 2 |
| UniProt Synonym Protein Names: | DOC-2; Differentially-expressed protein 2 |
| Protein Family: | Disabled |
| UniProt Gene Name: | DAB2 |
| UniProt Entry Name: | DAB2_HUMAN |
