| UniProt Protein Function: | CUEDC2: Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression. Belongs to the CUEDC2 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 10q24.32 Cellular Component: cytoplasm; nuclear membrane; nucleoplasm Molecular Function:protein binding |
| UniProt Code: | Q9H467 |
| NCBI GenInfo Identifier: | 74752634 |
| NCBI Gene ID: | 79004 |
| NCBI Accession: | Q9H467.1 |
| UniProt Secondary Accession: | Q9H467,Q9BWG8, D3DR88, |
| UniProt Related Accession: | Q9H467 |
| Molecular Weight: | 32,009 Da |
| NCBI Full Name: | CUE domain-containing protein 2 |
| NCBI Synonym Full Names: | CUE domain containing 2 |
| NCBI Official Symbol: | CUEDC2 |
| NCBI Official Synonym Symbols: | C10orf66; bA18I14.5 |
| NCBI Protein Information: | CUE domain-containing protein 2 |
| UniProt Protein Name: | CUE domain-containing protein 2 |
| Protein Family: | CUE domain-containing protein |
| UniProt Gene Name: | CUEDC2 |
| UniProt Entry Name: | CUED2_HUMAN |
