Description
| 抗体名: | CTNND2 Antibody, Biotin conjugated (PACO47245) |
| 抗体コード: | PACO47245 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Catenin delta-2 protein (4-308AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Biotin |
| バックグラウンド: | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. |
| シノニム: | Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin), CTNND2, NPRAP |
| UniProt Protein Function: | CTNND2: Functions as a transcriptional activator when bound to ZBTB33. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Interacts with PDZD2. Interacts with ZBTB33. Binds to PSEN1. Interacts with RGNEF. Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain). Predominantly expressed in brain; accumulates in cortical neurons. Belongs to the beta-catenin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 5p15.2 Cellular Component: cytoplasm; perikaryon Molecular Function:beta-catenin binding; protein binding Biological Process: cell adhesion; signal transduction; synapse organization and biogenesis Disease: Cri-du-chat Syndrome |
| NCBI Summary: | This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013] |
| UniProt Code: | Q9UQB3 |
| NCBI GenInfo Identifier: | 84028193 |
| NCBI Gene ID: | 1501 |
| NCBI Accession: | Q9UQB3.3 |
| UniProt Secondary Accession: | Q9UQB3,O00379, O15390, O43206, O43840, Q13589, Q9UM66 Q9UPM3, B0FTZ7, |
| UniProt Related Accession: | Q9UQB3 |
| Molecular Weight: | 126,529 Da |
| NCBI Full Name: | Catenin delta-2 |
| NCBI Synonym Full Names: | catenin delta 2 |
| NCBI Official Symbol: | CTNND2 |
| NCBI Official Synonym Symbols: | GT24; NPRAP |
| NCBI Protein Information: | catenin delta-2 |
| UniProt Protein Name: | Catenin delta-2 |
| UniProt Synonym Protein Names: | Delta-catenin; GT24; Neural plakophilin-related ARM-repeat protein; NPRAP; Neurojungin |
| Protein Family: | Catenin |
| UniProt Gene Name: | CTNND2 |
| UniProt Entry Name: | CTND2_HUMAN |
