Description
| 抗体名: | CST6 Antibody (PACO43948) |
| 抗体コード: | PACO43948 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Cystatin-M protein (29-149AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human skin tissue using PACO43948 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO43948 at dilution of 1:100. |
| バックグラウンド: | Shows moderate inhibition of cathepsin B but is not active against cathepsin C. |
| シノニム: | Cystatin-M (Cystatin-6) (Cystatin-E), CST6 |
| UniProt Protein Function: | CST6: Shows moderate inhibition of cathepsin B but is not active against cathepsin C. Belongs to the cystatin family. |
| UniProt Protein Details: | Protein type:Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11q13 Cellular Component: cornified envelope Molecular Function:cysteine protease inhibitor activity Biological Process: epidermis development; anatomical structure morphogenesis |
| NCBI Summary: | The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15828 |
| NCBI GenInfo Identifier: | 4503113 |
| NCBI Gene ID: | 1474 |
| NCBI Accession: | NP_001314.1 |
| UniProt Secondary Accession: | Q15828,Q540N7, |
| UniProt Related Accession: | Q15828 |
| Molecular Weight: | 16,511 Da |
| NCBI Full Name: | cystatin-M |
| NCBI Synonym Full Names: | cystatin E/M |
| NCBI Official Symbol: | CST6 |
| NCBI Protein Information: | cystatin-M; cystatin 6; cystatin M; cystatin-6; cystatin-E; cystatin M/E; cysteine proteinase inhibitor |
| UniProt Protein Name: | Cystatin-M |
| UniProt Synonym Protein Names: | Cystatin-6; Cystatin-E |
| Protein Family: | Cystatin |
| UniProt Gene Name: | CST6 |
| UniProt Entry Name: | CYTM_HUMAN |
