Description
| 抗体名: | CSE1L Antibody |
| 抗体コード: | PACO00514 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC, IF, IP |
| 推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300, IP:2-5ug, IF:1:200-1:1000, |
| 反応性: | Human |
| 免疫原: | synthesized peptide derived from the N-terminal region of human CAS. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | CSE1L; CAS; XPO2; Exportin-2; Exp2; Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter |
| UniProt Protein Function: | Exportin-2: Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the XPO2/CSE1 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear export; Karyopherin; Nuclear import Chromosomal Location of Human Ortholog: 20q13 Cellular Component: cytoplasm; cytosol; membrane; nuclear envelope; nucleoplasm; nucleus Molecular Function:nuclear export signal receptor activity; protein binding Biological Process: apoptosis; cell proliferation; protein import into nucleus |
| NCBI Summary: | Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P55060 |
| NCBI GenInfo Identifier: | 62297557 |
| NCBI Gene ID: | 1434 |
| NCBI Accession: | P55060.3 |
| UniProt Secondary Accession: | P55060,O75432, Q32M40, Q9H5B7, Q9NTS0, Q9UP98, Q9UP99 Q9UPA0, A3RLL6, B2R5T4, E1P5Y0, F8W904, |
| UniProt Related Accession: | P55060 |
| Molecular Weight: | 103,879 Da |
| NCBI Full Name: | Exportin-2 |
| NCBI Synonym Full Names: | chromosome segregation 1 like |
| NCBI Official Symbol: | CSE1L |
| NCBI Official Synonym Symbols: | CAS; CSE1; XPO2 |
| NCBI Protein Information: | exportin-2 |
| UniProt Protein Name: | Exportin-2 |
| UniProt Synonym Protein Names: | Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter |
| UniProt Gene Name: | CSE1L |
| UniProt Entry Name: | XPO2_HUMAN |