The CRTAP Polyclonal Antibody (CAB4428) is a valuable tool for researchers studying the role of CRTAP, a protein involved in collagen synthesis and bone development. This antibody, produced in rabbits, is highly specific to human samples and is optimized for use in Western blotting applications. By binding to the CRTAP protein, this antibody allows for the accurate detection and analysis of CRTAP levels in various cell types.CRTAP, also known as cartilage-associated protein, plays a crucial role in collagen modification and is essential for the proper formation of collagen fibers in bone tissue.
Mutations in the CRTAP gene have been linked to bone disorders such as Osteogenesis Imperfecta, highlighting the importance of studying this protein in the context of bone health and disease.By using the CRTAP Polyclonal Antibody in their research, scientists can gain valuable insights into the function of CRTAP and its role in collagen metabolism. This antibody is a valuable tool for studies exploring bone development, collagen synthesis, and related disorders, ultimately contributing to our understanding of skeletal health and potential therapeutic targets.
Product Name:
CRTAP Rabbit Polyclonal Antibody
SKU:
CAB4428
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-240 of human CRTAP (NP_006362.1).
The protein encoded by this gene is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli. Defects in this gene are associated with osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility and low bone mass.
Purification Method:
Affinity purification
Gene ID:
10491
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from SW480 cells, using CRTAP Rabbit pAb (CAB4428) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
