Description
| 抗体名: | CRADD Antibody (PACO08586) |
| 抗体コード: | PACO08586 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human CRADD |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | CASP2 and RIPK1 domain containing adaptor with death domain;CRADD;MGC9163;RAIDD ; |
| UniProt Protein Function: | CRADD: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non- syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Apoptosis Chromosomal Location of Human Ortholog: 12q21.33-q23.1 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding, bridging; protein binding; protease binding Biological Process: caspase activation; induction of apoptosis via death domain receptors; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Disease: Mental Retardation, Autosomal Recessive 34 |
| NCBI Summary: | This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] |
| UniProt Code: | P78560 |
| NCBI GenInfo Identifier: | 2498833 |
| NCBI Gene ID: | 8738 |
| NCBI Accession: | P78560.1 |
| UniProt Related Accession: | P78560 |
| Molecular Weight: | ~ 23kDa |
| NCBI Full Name: | Death domain-containing protein CRADD |
| NCBI Synonym Full Names: | CASP2 and RIPK1 domain containing adaptor with death domain |
| NCBI Official Symbol: | CRADD |
| NCBI Official Synonym Symbols: | MRT34; RAIDD |
| NCBI Protein Information: | death domain-containing protein CRADD |
| UniProt Protein Name: | Death domain-containing protein CRADD |
| UniProt Synonym Protein Names: | Caspase and RIP adapter with death domain; RIP-associated protein with a death domain |
| UniProt Gene Name: | CRADD |
| UniProt Entry Name: | CRADD_HUMAN |
