Description
| 抗体名: | CPB2 Antibody |
| 抗体コード: | PACO03478 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | WB:1:500-1:2000 |
| 反応性: | Human |
| 免疫原: | synthesized peptide derived from the C-terminal region of human TAFI. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | CPB2; Carboxypeptidase B2; Carboxypeptidase U; CPU; Plasma carboxypeptidase B; pCPB; Thrombin-activable fibrinolysis inhibitor; TAFI |
| UniProt Protein Function: | CPB2: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.17.20; Secreted, signal peptide; Secreted; Protease Chromosomal Location of Human Ortholog: 13q14.11 Cellular Component: extracellular space Molecular Function:zinc ion binding; metallocarboxypeptidase activity Biological Process: response to drug; fibrinolysis; negative regulation of fibrinolysis; response to heat; blood coagulation; proteolysis |
| NCBI Summary: | Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] |
| UniProt Code: | Q96IY4 |
| NCBI GenInfo Identifier: | 317373332 |
| NCBI Gene ID: | 1361 |
| NCBI Accession: | Q96IY4.2 |
| UniProt Secondary Accession: | Q96IY4,Q15114, Q5T9K1, Q5T9K2, Q9P2Y6, A8K464, |
| UniProt Related Accession: | Q96IY4 |
| Molecular Weight: | 423 |
| NCBI Full Name: | Carboxypeptidase B2 |
| NCBI Synonym Full Names: | carboxypeptidase B2 (plasma) |
| NCBI Official Symbol: | CPB2 |
| NCBI Official Synonym Symbols: | CPU; PCPB; TAFI |
| NCBI Protein Information: | carboxypeptidase B2; carboxypeptidase R; carboxypeptidase B-like protein; thrombin-activable fibrinolysis inhibitor; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase B2 (plasma, carboxypeptidase U) |
| UniProt Protein Name: | Carboxypeptidase B2 |
| UniProt Synonym Protein Names: | Carboxypeptidase U; CPU; Plasma carboxypeptidase B; pCPB; Thrombin-activable fibrinolysis inhibitor; TAFI |
| Protein Family: | Carboxypeptidase |
| UniProt Gene Name: | CPB2 |
| UniProt Entry Name: | CBPB2_HUMAN |
