Description
| 抗体名: | COTL1 Antibody (PACO43713) |
| 抗体コード: | PACO43713 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
| 反応性: | Human, Mouse |
| 免疫原: | Recombinant Human Coactosin-like protein (1-142AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: COTL1 antibody at 5µg/ml. Lane 1: Mouse brain tissue. Lane 2: Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 16 kDa. Observed band size: 16 kDa. |
 | Immunohistochemistry of paraffin-embedded human lung cancer using PACO43713 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human breast cancer using PACO43713 at dilution of 1:100. |
| バックグラウンド: | Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. |
| シノニム: | Coactosin-like protein, COTL1, CLP |
| UniProt Protein Function: | COTL1: Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Belongs to the actin-binding proteins ADF family. Coactosin subfamily. |
| UniProt Protein Details: | Protein type:Actin-binding Chromosomal Location of Human Ortholog: 16q24.1 Cellular Component: nuclear membrane; cytoskeleton; cytoplasm Molecular Function:protein binding; enzyme binding; actin binding Biological Process: defense response to fungus |
| NCBI Summary: | This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14019 |
| NCBI GenInfo Identifier: | 21759076 |
| NCBI Gene ID: | 23406 |
| NCBI Accession: | Q14019.3 |
| UniProt Related Accession: | Q14019 |
| Molecular Weight: | |
| NCBI Full Name: | Coactosin-like protein |
| NCBI Synonym Full Names: | coactosin like F-actin binding protein 1 |
| NCBI Official Symbol: | COTL1 |
| NCBI Official Synonym Symbols: | CLP |
| NCBI Protein Information: | coactosin-like protein |
| UniProt Protein Name: | Coactosin-like protein |
| Protein Family: | Coactosin-like protein |
| UniProt Gene Name: | COTL1 |
| UniProt Entry Name: | COTL1_HUMAN |
| Antibodies | ELISA Kits |
| Anti-COTL1 Antibody (CAB4550) | Human Coactosin-like Protein 1 / COTL1 ELISA Kit |
| COTL1 Antibody (PACO08539) | Human Coactosin-like protein (COTL1) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
