Description
| 抗体名: | COQ7 Antibody (PACO43712) |
| 抗体コード: | PACO43712 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human 5-demethoxyubiquinone hydroxylase, mitochondrial protein (37-217AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human breast cancer using PACO43712 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO43712 at dilution of 1:100. |
| バックグラウンド: | Involved in lifespan determination in ubiquinone-independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator (By similarity). |
| シノニム: | 5-demethoxyubiquinone hydroxylase, mitochondrial (DMQ hydroxylase) (EC 1.14.13.-) (Timing protein clk-1 homolog) (Ubiquinone biosynthesis monooxygenase COQ7), COQ7 |
| UniProt Protein Function: | COQ7: Involved in lifespan determination in ubiquinone- independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator. Belongs to the COQ7 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; Mitochondrial Chromosomal Location of Human Ortholog: 16p12.3 Cellular Component: mitochondrial inner membrane; nucleus Molecular Function:metal ion binding Biological Process: ubiquinone biosynthetic process; neurogenesis; in utero embryonic development; determination of adult life span; neural tube formation; age-dependent response to oxidative stress; organelle ATP synthesis coupled electron transport |
| NCBI Summary: | The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010] |
| UniProt Code: | Q99807 |
| NCBI GenInfo Identifier: | 311033465 |
| NCBI Gene ID: | 10229 |
| NCBI Accession: | Q99807.3 |
| UniProt Related Accession: | Q99807 |
| Molecular Weight: | ~ 24kDa |
| NCBI Full Name: | 5-demethoxyubiquinone hydroxylase, mitochondrial |
| NCBI Synonym Full Names: | coenzyme Q7, hydroxylase |
| NCBI Official Symbol: | COQ7 |
| NCBI Official Synonym Symbols: | CAT5; CLK1; CLK-1; COQ10D8 |
| NCBI Protein Information: | 5-demethoxyubiquinone hydroxylase, mitochondrial |
| UniProt Protein Name: | Ubiquinone biosynthesis protein COQ7 homolog |
| UniProt Synonym Protein Names: | Coenzyme Q biosynthesis protein 7 homolog; Timing protein clk-1 homolog |
| Protein Family: | 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase |
| UniProt Gene Name: | COQ7 |
| UniProt Entry Name: | COQ7_HUMAN |
