Description
| 抗体名: | CLNS1A Antibody |
| 抗体コード: | PACO01337 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | WB:1:500-1:2000 |
| 反応性: | Human |
| 免疫原: | synthesized peptide derived from the C-terminal region of human pICln. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | CLNS1A; CLCI; ICLN; Methylosome subunit pICln; Chloride channel; nucleotide sensitive 1A; Chloride conductance regulatory protein ICln; I(Cln); Chloride ion current inducer protein; ClCI; Reticulocyte pICln |
| UniProt Protein Function: | ICLN: The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. Belongs to the pICln (TC 1.A.47) family. |
| UniProt Protein Details: | Protein type:Channel, chloride Chromosomal Location of Human Ortholog: 11q13.5-q14 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:protein binding; protein heterodimerization activity Biological Process: spliceosomal snRNP biogenesis |
| NCBI Summary: | This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015] |
| UniProt Code: | P54105 |
| NCBI GenInfo Identifier: | 1708393 |
| NCBI Gene ID: | 1207 |
| NCBI Accession: | P54105.1 |
| UniProt Secondary Accession: | P54105,Q0VDK6, Q9NRD2, Q9NRD3, B2RCS9, |
| UniProt Related Accession: | P54105 |
| Molecular Weight: | 26,215 Da |
| NCBI Full Name: | Methylosome subunit pICln |
| NCBI Synonym Full Names: | chloride nucleotide-sensitive channel 1A |
| NCBI Official Symbol: | CLNS1A |
| NCBI Official Synonym Symbols: | CLCI; ICln; CLNS1B |
| NCBI Protein Information: | methylosome subunit pICln |
| UniProt Protein Name: | Methylosome subunit pICln |
| UniProt Synonym Protein Names: | Chloride channel, nucleotide sensitive 1A; Chloride conductance regulatory protein ICln; I(Cln); Chloride ion current inducer protein; ClCI; Reticulocyte pICln |
| UniProt Gene Name: | CLNS1A |
| UniProt Entry Name: | ICLN_HUMAN |
