Description
| 抗体名: | CLK1 Antibody (PACO23226) |
| 抗体コード: | PACO23226 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IF |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IF:1:100-1:500 |
| 反応性: | Human, Mouse |
| 免疫原: | Synthesized peptide derived from internal of human CLK1. |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from 293 cells, using CLK1 antibody. |
 | Immunofluorescence analysis of HUVEC cells, using CLK1 antibody. |
| バックグラウンド: | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA. |
| シノニム: | CDC like kinase 1; CLK; CLK1; Dual specificity protein kinase CLK1; EC 2.7.1.112 |
| UniProt Protein Function: | CLK1: a CMGC kinase of the CLK family. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May play a role in regulating RNA splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, dual-specificity (non-receptor); Protein kinase, CMGC; EC 2.7.12.1; Kinase, protein; CMGC group; CLK family Chromosomal Location of Human Ortholog: 2q33 Cellular Component: cytoplasm; nucleus Molecular Function:protein serine/threonine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; ATP binding Biological Process: cell proliferation; peptidyl-serine phosphorylation; peptidyl-tyrosine phosphorylation; regulation of RNA splicing; protein amino acid autophosphorylation; peptidyl-threonine phosphorylation |
| NCBI Summary: | This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009] |
| UniProt Code: | P49759 |
| NCBI GenInfo Identifier: | 206729857 |
| NCBI Gene ID: | 1195 |
| NCBI Accession: | P49759.2 |
| UniProt Secondary Accession: | P49759,Q0P694, Q8N5V8, B4DFW7, |
| UniProt Related Accession: | P49759 |
| Molecular Weight: | 484 |
| NCBI Full Name: | Dual specificity protein kinase CLK1 |
| NCBI Synonym Full Names: | CDC-like kinase 1 |
| NCBI Official Symbol: | CLK1 |
| NCBI Official Synonym Symbols: | CLK; STY; CLK/STY |
| NCBI Protein Information: | dual specificity protein kinase CLK1; CDC28/CDC2-like kinase; protein tyrosine kinase STY |
| UniProt Protein Name: | Dual specificity protein kinase CLK1 |
| UniProt Synonym Protein Names: | CDC-like kinase 1 |
| Protein Family: | Dual specificity protein kinase |
| UniProt Gene Name: | CLK1 |
| UniProt Entry Name: | CLK1_HUMAN |
