Description
| 抗体名: | CLDN3 Antibody (PACO23641) |
| 抗体コード: | PACO23641 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC, IF |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
| 反応性: | Human |
| 免疫原: | Synthesized peptide derived from human Claudin 3. |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HuvEc cells, using Claudin 3 antibody. |
 | Immunofluorescence analysis of HuvEc cells, using Claudin 3 antibody. |
 | Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using Claudin 3 antibody. |
| バックグラウンド: | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity. |
| シノニム: | CLD3; CLDN3; CPE-R 2; CPE-receptor 2; Clostridium perfringens enterotoxin receptor 2 |
| UniProt Protein Function: | Claudin-3: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the claudin family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Cytoskeletal Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: apicolateral plasma membrane; integral to membrane; integral to plasma membrane; lateral plasma membrane; tight junction Molecular Function:identical protein binding; structural molecule activity; transmembrane receptor activity Biological Process: calcium-independent cell-cell adhesion; protein heterooligomerization; protein homooligomerization; response to hypoxia; signal transduction |
| NCBI Summary: | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15551 |
| NCBI GenInfo Identifier: | 6685273 |
| NCBI Gene ID: | 1365 |
| NCBI Accession: | O15551.1 |
| UniProt Secondary Accession: | O15551,Q9Z0G9, Q63400, |
| UniProt Related Accession: | O15551 |
| Molecular Weight: | 23,319 Da |
| NCBI Full Name: | Claudin-3 |
| NCBI Synonym Full Names: | claudin 3 |
| NCBI Official Symbol: | CLDN3 |
| NCBI Official Synonym Symbols: | RVP1; HRVP1; C7orf1; CPE-R2; CPETR2 |
| NCBI Protein Information: | claudin-3 |
| UniProt Protein Name: | Claudin-3 |
| UniProt Synonym Protein Names: | Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-receptor 2; Rat ventral prostate.1 protein homolog; hRVP1 |
| Protein Family: | Claudin |
| UniProt Gene Name: | CLDN3 |
| UniProt Entry Name: | CLD3_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
