Description
| 抗体名: | CISH Antibody (PACO43449) |
| 抗体コード: | PACO43449 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Cytokine-inducible SH2-containing protein (1-257AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human colon tissue using PACO43449 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43449 at dilution of 1:100. |
| バックグラウンド: | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| シノニム: | Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS), CISH, G18 |
| UniProt Protein Function: | CISH: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Stably associated with the tyrosine-phosphorylated IL3 receptor beta chain and tyrosine-phosphorylated EPO receptor (EPOR). By a subset of cytokines including EPO/erythropoietin. Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 3p21.3 Cellular Component: cytoplasm; plasma membrane; cytosol Molecular Function:protein binding; protein kinase inhibitor activity Biological Process: cytokine and chemokine mediated signaling pathway; protein kinase C activation; negative regulation of insulin receptor signaling pathway; negative regulation of protein kinase activity; protein ubiquitination; regulation of cell growth; negative regulation of JAK-STAT cascade Disease: Mycobacterium Tuberculosis, Susceptibility To; Bacteremia, Susceptibility To, 2; Malaria, Susceptibility To |
| NCBI Summary: | The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| UniProt Code: | Q9NSE2 |
| NCBI GenInfo Identifier: | 13124022 |
| NCBI Gene ID: | 1154 |
| NCBI Accession: | Q9NSE2.1 |
| UniProt Secondary Accession: | Q9NSE2,Q9NS38, Q9Y5R1, B2R9N1, G5E9R1, |
| UniProt Related Accession: | Q9NSE2 |
| Molecular Weight: | 30,734 Da |
| NCBI Full Name: | Cytokine-inducible SH2-containing protein |
| NCBI Synonym Full Names: | cytokine inducible SH2-containing protein |
| NCBI Official Symbol: | CISH |
| NCBI Official Synonym Symbols: | CIS; G18; SOCS; CIS-1; BACTS2 |
| NCBI Protein Information: | cytokine-inducible SH2-containing protein; suppressor of cytokine signaling; cytokine-inducible inhibitor of signaling type 1B |
| UniProt Protein Name: | Cytokine-inducible SH2-containing protein |
| UniProt Synonym Protein Names: | CIS-1; Protein G18; Suppressor of cytokine signaling; SOCS |
| Protein Family: | Cis-abienol synthase |
| UniProt Gene Name: | CISH |
| UniProt Entry Name: | CISH_HUMAN |
