Description
| 抗体名: | CHRNA10 Antibody (PACO45419) |
| 抗体コード: | PACO45419 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Neuronal acetylcholine receptor subunit alpha-10 protein (25-240AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: CHRNA10 antibody at 0.57µg/ml. Lane 1: Jurkat whole cell lysate. Lane 2: A549 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 50 kDa. Observed band size: 50 kDa.. |
 | Immunohistochemistry of paraffin-embedded human thymus tissue using PACO45419 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO45419 at dilution of 1:100. |
| バックグラウンド: | Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. |
| シノニム: | Neuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10), CHRNA10, NACHRA10 |
| UniProt Protein Function: | nAChRA10: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 10/CHRNA10 sub-subfamily. |
| UniProt Protein Details: | Protein type:Channel, cation; Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: membrane; nicotinic acetylcholine-gated receptor-channel complex Molecular Function:acetylcholine binding; acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; receptor binding Biological Process: elevation of cytosolic calcium ion concentration; regulation of cell proliferation; synaptic transmission, cholinergic |
| UniProt Code: | Q9GZZ6 |
| NCBI GenInfo Identifier: | 14916526 |
| NCBI Gene ID: | 57053 |
| NCBI Accession: | Q9GZZ6.1 |
| UniProt Related Accession: | Q9GZZ6 |
| Molecular Weight: | 49,705 Da |
| NCBI Full Name: | Neuronal acetylcholine receptor subunit alpha-10 |
| NCBI Synonym Full Names: | cholinergic receptor nicotinic alpha 10 subunit |
| NCBI Official Symbol: | CHRNA10 |
| NCBI Protein Information: | neuronal acetylcholine receptor subunit alpha-10 |
| UniProt Protein Name: | Neuronal acetylcholine receptor subunit alpha-10 |
| UniProt Synonym Protein Names: | Nicotinic acetylcholine receptor subunit alpha-10; NACHR alpha-10 |
| Protein Family: | Neuronal acetylcholine receptor |
| UniProt Gene Name: | CHRNA10 |
| UniProt Entry Name: | ACH10_HUMAN |
