Anti-CHKB 抗体 (PACO21987)

抗体名:	CHKB Antibody (PACO21987)
抗体コード:	PACO21987
サイズ:	100ul
宿主種:	Rabbit
申し込み:	ELISA, WB
推奨される希釈:	ELISA:1:2000-1:10000, WB:1:500-1:3000
反応性:	Human
免疫原:	Synthesized peptide derived from internal of human CHKB.

憲法:	Liquid
ストレージバッファ:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
精製方法:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
抗体のクローン性:	Polyclonal
アイソタイプ:	IgG
Conjugate:	Non-conjugated

Western blot analysis of extracts from HepG2 cells and A549 cells, using CHKB antibody.

バックグラウンド:	Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis. Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).
シノニム:	Choline/ethanolamine kinase; Choline kinase β (EC 2.7.1.32)(CK); Ethanolamine kinase (EC 2.7.1.82)(EK); CHKB; CHETK

UniProt Protein Function:	CHKB: Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis. Belongs to the choline/ethanolamine kinase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 2.7.1.82; Kinase, other; Lipid Metabolism - glycerophospholipid; EC 2.7.1.32Chromosomal Location of Human Ortholog: 22q13.33Cellular Component: cytosolMolecular Function: ATP binding; choline kinase activity; ethanolamine kinase activityBiological Process: CDP-choline pathway; glycerophospholipid biosynthetic process; phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process; phospholipid metabolic process; phosphorylationDisease: Muscular Dystrophy, Congenital, Megaconial Type
UniProt Protein Details:
NCBI Summary:	Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. [provided by RefSeq, Jun 2009]
UniProt Code:	Q9Y259
NCBI GenInfo Identifier:	6685604
NCBI Gene ID:	1120
NCBI Accession:	Q9Y259.3
UniProt Secondary Accession:	Q9Y259,Q13388, A0PJM6
UniProt Related Accession:	Q9Y259
Molecular Weight:	13,506 Da
NCBI Full Name:	Choline/ethanolamine kinase
NCBI Synonym Full Names:	choline kinase beta
NCBI Official Symbol:	CHKB
NCBI Official Synonym Symbols:	CK; EK; CKB; EKB; CHKL; CHETK; CKEKB; MDCMC
NCBI Protein Information:	choline/ethanolamine kinase
UniProt Protein Name:	Choline/ethanolamine kinase
UniProt Synonym Protein Names:	Choline kinase beta (EC:2.7.1.32); CK; CKB; Choline kinase-like protein; Ethanolamine kinase (EC:2.7.1.82); EK; Ethanolamine kinase beta; EKB; choline/ethanolamine kinase beta; CKEKB
Protein Family:	Choline/ethanolamine kinase
UniProt Gene Name:	CHKB
UniProt Entry Name:	CHKB_HUMAN

Antibodies

CHKB Antibody (PACO00598)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)