| UniProt Protein Function: | CHGB: a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 20p12.3 Cellular Component: extracellular region; secretory granule Molecular Function:protein binding; hormone activity |
| NCBI Summary: | This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009] |
| UniProt Code: | P05060 |
| NCBI GenInfo Identifier: | 311033509 |
| NCBI Gene ID: | 1114 |
| NCBI Accession: | P05060.2 |
| UniProt Secondary Accession: | P05060,Q59EU9, Q6IBS6, Q9BQV6, Q9UC25, Q9UJA6, A8K021 |
| UniProt Related Accession: | P05060 |
| Molecular Weight: | 78kDa |
| NCBI Full Name: | Secretogranin-1 |
| NCBI Synonym Full Names: | chromogranin B (secretogranin 1) |
| NCBI Official Symbol: | CHGB |
| NCBI Official Synonym Symbols: | SCG1 |
| NCBI Protein Information: | secretogranin-1; cgB; sgI; chromogranin-B; secretogranin B; secretogranin I |
| UniProt Protein Name: | Secretogranin-1 |
| UniProt Synonym Protein Names: | Chromogranin-B; CgB; Secretogranin I; SgI |
| Protein Family: | Secretogranin |
| UniProt Gene Name: | CHGB |
| UniProt Entry Name: | SCG1_HUMAN |
