Description
| 抗体名: | CD8B Antibody (PACO45341) |
| 抗体コード: | PACO45341 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human T-cell surface glycoprotein CD8 β chain protein (22-170AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO45341 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO45341 at dilution of 1:100. |
| バックグラウンド: | Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. |
| シノニム: | T-cell surface glycoprotein CD8 β chain (CD antigen CD8b), CD8B, CD8B1 |
| UniProt Protein Function: | CD8B: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 2p12 Cellular Component: T cell receptor complex; integral to plasma membrane; early endosome membrane; plasma membrane; extracellular region; external side of plasma membrane Molecular Function:protein binding; MHC class I protein binding; coreceptor activity Biological Process: regulation of immune response; T cell activation; viral reproduction; immune response; regulation of defense response to virus by virus; transmembrane receptor protein tyrosine kinase signaling pathway |
| NCBI Summary: | The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010] |
| UniProt Code: | P10966 |
| NCBI GenInfo Identifier: | 116032 |
| NCBI Gene ID: | 926 |
| NCBI Accession: | P10966.1 |
| UniProt Secondary Accession: | P10966,P14860, P14861, Q15980, Q496E0, Q496E1, Q496E2 Q9UDB4, Q9UDB5, Q9UDB6, Q9UDB7, Q9UDB8, |
| UniProt Related Accession: | P10966 |
| Molecular Weight: | 210 |
| NCBI Full Name: | T-cell surface glycoprotein CD8 beta chain |
| NCBI Synonym Full Names: | CD8b molecule |
| NCBI Official Symbol: | CD8B |
| NCBI Official Synonym Symbols: | LY3; P37; LEU2; LYT3; CD8B1 |
| NCBI Protein Information: | T-cell surface glycoprotein CD8 beta chain; CD8 antigen, beta polypeptide 1 (p37); T lymphocyte surface glycoprotein beta chain |
| UniProt Protein Name: | T-cell surface glycoprotein CD8 beta chain |
| UniProt Synonym Protein Names: | CD_antigen: CD8b |
| Protein Family: | T-cell surface glycoprotein |
| UniProt Gene Name: | CD8B |
| UniProt Entry Name: | CD8B_HUMAN |
