CD80 monoclonal antibody (APC ) (AGIM0062)

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SKU:
AGIM0062
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
MEM-233
Conjugation:
APC
Applications:
FC
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Description

system_update_altDatasheet
Product Name:CD80 monoclonal antibody (APC )
Product Code:AGIM0062
Size:500 µL
Reactivity:Human
Clone:MEM-233
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Do not freeze. Avoid prolonged exposure to light.
Uniprot:P33681
Background:CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigenpresenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
UniProt Protein Function:Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
NCBI Summary:The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
UniProt Code:P33681
NCBI GenInfo Identifier:461606
NCBI Gene ID:941
NCBI Accession:P33681.1
UniProt Secondary Accession:P33681,Q5DTA9, Q5DTB0,
UniProt Related Accession:P33681
Molecular Weight:18,761 Da
NCBI Full Name:T-lymphocyte activation antigen CD80
NCBI Synonym Full Names:CD80 molecule
NCBI Official Symbol:CD80  
NCBI Official Synonym Symbols:B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1  
NCBI Protein Information:T-lymphocyte activation antigen CD80
UniProt Protein Name:T-lymphocyte activation antigen CD80
UniProt Synonym Protein Names:Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7; CD_antigen: CD80
Protein Family:T-lymphocyte activation antigen
UniProt Gene Name:CD80  
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