| UniProt Protein Function: | CD33: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:protein binding; receptor activity; carbohydrate binding Biological Process: negative regulation of cell proliferation; cell-cell signaling; signal transduction; cell adhesion |
| UniProt Code: | P20138 |
| NCBI GenInfo Identifier: | 116241290 |
| NCBI Gene ID: | 945 |
| NCBI Accession: | P20138.2 |
| UniProt Secondary Accession: | P20138,Q8TD24, B4E3P8, C9JEN7, F8WAL2, |
| UniProt Related Accession: | P20138 |
| Molecular Weight: | Calculated MW: 25kDa/33kDa/39kDaObserved MW: 77kDa |
| NCBI Full Name: | Myeloid cell surface antigen CD33 |
| NCBI Synonym Full Names: | CD33 molecule |
| NCBI Official Symbol: | CD33 |
| NCBI Official Synonym Symbols: | p67; SIGLEC3; SIGLEC-3 |
| NCBI Protein Information: | myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3 |
| UniProt Protein Name: | Myeloid cell surface antigen CD33 |
| UniProt Synonym Protein Names: | Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD_antigen: CD33 |
| Protein Family: | Myeloid cell surface antigen |
| UniProt Gene Name: | CD33 |
| UniProt Entry Name: | CD33_HUMAN |
![PE Anti-Human CD33 Antibody [6C5] (AGEL2846)](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/590x590/products/179397/179131/pe-anti-human-cd33-antibody-6c5-agel2846__51105__78994.1750452740.jpg?c=1 "PE Anti-Human CD33 Antibody [6C5] (AGEL2846)")