| UniProt Protein Function: | Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34+ cells to the stroma and by negatively regulating CD34+CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes. |
| NCBI Summary: | This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of hematopoietic progenitor cells. The encoded protein also interacts with the C-X-C chemokine receptor type 4 and may regulate muscle development. Elevated expression of this gene has been observed in human patients with Sezary syndrome, a type of blood cancer, and a mutation in this gene may be associated with impaired hearing. [provided by RefSeq, Oct 2016] |
| UniProt Code: | Q04900 |
| NCBI GenInfo Identifier: | 257051036 |
| NCBI Gene ID: | 8763 |
| NCBI Accession: | Q04900.2 |
| UniProt Related Accession: | Q04900 |
| Molecular Weight: | 16kDa; 19kDa; 20kDa |
| NCBI Full Name: | Sialomucin core protein 24 |
| NCBI Synonym Full Names: | CD164 molecule |
| NCBI Official Symbol: | CD164 |
| NCBI Official Synonym Symbols: | DFNA66; MGC-24; MUC-24; MGC-24v; endolyn |
| NCBI Protein Information: | sialomucin core protein 24 |
| UniProt Protein Name: | Sialomucin core protein 24 |
| UniProt Synonym Protein Names: | Endolyn; Multi-glycosylated core protein 24; MGC-24; MGC-24v; CD_antigen: CD164 |
| Protein Family: | CD164 sialomucin-like 2 protein |
| UniProt Gene Name: | CD164 |
