| UniProt Protein Function: | Receptor showing broad specificity for both classical and non-classical MHC class I molecules. |
| NCBI Summary: | CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95971 |
| NCBI GenInfo Identifier: | 17372903 |
| NCBI Gene ID: | 11126 |
| NCBI Accession: | O95971.1 |
| UniProt Related Accession: | O95971 |
| Molecular Weight: | 19,810 Da |
| NCBI Full Name: | CD160 antigen |
| NCBI Synonym Full Names: | CD160 molecule |
| NCBI Official Symbol: | CD160 |
| NCBI Official Synonym Symbols: | NK1; BY55; NK28 |
| NCBI Protein Information: | CD160 antigen |
| UniProt Protein Name: | CD160 antigen |
| UniProt Synonym Protein Names: | Natural killer cell receptor BY55; CD_antigen: CD160 |
| Protein Family: | CD160 antigen |
| UniProt Gene Name: | CD160 |
