Description
| 抗体名: | CCT5 Antibody (PACO44366) |
| 抗体コード: | PACO44366 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC, IP |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IP:1:200-1:2000 |
| 反応性: | Human |
| 免疫原: | Recombinant Human T-complex protein 1 subunit epsilon protein (1-270AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: CCT5 antibody at 1.78µg/ml. Lane 1: Hela whole cell lysate. Lane 2: Colo320 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 60, 50 kDa. Observed band size: 60 kDa.. |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO44366 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO44366 at dilution of 1:100. |
| バックグラウンド: | Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. |
| シノニム: | T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon), CCT5, CCTE KIAA0098 |
| UniProt Protein Function: | CCT-epsilon: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. Defects in CCT5 are the cause of hereditary sensory neuropathy autosomal recessive with spastic paraplegia (HSNSP). The disease is characterized by spastic paraplegia and progressive distal sensory neuropathy leading to mutilating ulcerations of the upper and lower limbs. Belongs to the TCP-1 chaperonin family. |
| UniProt Protein Details: | Protein type:Chaperone Chromosomal Location of Human Ortholog: 5p15.2 Cellular Component: chaperonin-containing T-complex; centrosome; microtubule; cytoplasm; nucleolus; cytosol Molecular Function:protein binding; unfolded protein binding; beta-tubulin binding; G-protein beta-subunit binding; ATP binding Biological Process: 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; binding of sperm to zona pellucida; response to virus Disease: Neuropathy, Hereditary Sensory, With Spastic Paraplegia, Autosomal Recessive |
| NCBI Summary: | The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. In addition, three pseudogenes of this gene have been identified. [provided by RefSeq, Jun 2010] |
| UniProt Code: | P48643 |
| NCBI GenInfo Identifier: | 1351211 |
| NCBI Gene ID: | 22948 |
| NCBI Accession: | P48643.1 |
| UniProt Secondary Accession: | P48643,A8JZY8, A8K2X8, B4DYD8, |
| UniProt Related Accession: | P48643 |
| Molecular Weight: | 541 |
| NCBI Full Name: | T-complex protein 1 subunit epsilon |
| NCBI Synonym Full Names: | chaperonin containing TCP1, subunit 5 (epsilon) |
| NCBI Official Symbol: | CCT5 |
| NCBI Official Synonym Symbols: | CCTE; HEL-S-69; CCT-epsilon; TCP-1-epsilon |
| NCBI Protein Information: | T-complex protein 1 subunit epsilon; epididymis secretory protein Li 69; T-complex protein 1, epsilon subunit |
| UniProt Protein Name: | T-complex protein 1 subunit epsilon |
| UniProt Synonym Protein Names: | CCT-epsilon |
| Protein Family: | T-complex protein |
| UniProt Gene Name: | CCT5 |
| UniProt Entry Name: | TCPE_HUMAN |
